What question did this study set out to answer?

This research aims to explore the effects of a germ-line deletion of the Csf1r enhancer on tissue resident macrophages in mice.

June 28, 2026DevelopmentOpen Access

Depletion and replacement of tissue resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus

View Full Paper

Ask AI

Bookmark

Authors

LYLiu YTranslational Research Institute SJSébastien JacquelinTranslational Research Institute ITIsis TaylorTranslational Research Institute

Discussion

Member takes

Implication

Randomized trial investigates macrophage depletion and replacement in mice with Csf1r enhancer deletion, suggesting potential insights into their functions.

Key Points

This research aims to explore the effects of a germ-line deletion of the Csf1r enhancer on tissue resident macrophages in mice.
Performed gene expression analysis to assess CSF1R in bone marrow progenitors and monocytes.
Evaluated macrophage recruitment and tissue macrophage dynamics after bone marrow transplantation.
Measured physiological outcomes in heart and kidney functions in Fireko mice.
CSF1R is undetectable in bone marrow progenitors and classical monocytes in Fireko mice.
Heart and kidney functions remain stable despite the absence of macrophages.
Fireko mice exhibit male-specific increases in serum creatinine and urea following renal injury.

Cite This Study

Y et al. (2026) studied this question.

synapsesocial.com/papers/6a40ba5661bb0a67205c63e6 https://doi.org/10.1242/dev.205655

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial investigates macrophage depletion and replacement in mice with Csf1r enhancer deletion, suggesting potential insights into their functions.

Depletion and replacement of tissue resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus

Discussion

Member takes

Implication

Key Points

Cite This Study

Depletion and replacement of tissue resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider