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June 28, 2026Journal of Comparative PathologyOpen Access

Immunohistochemical characterization of immune cell and metabolic markers in canine prostate carcinoma

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Authors

TKTaiki KatoYamaguchi University MSMasashi SakuraiSetsunan University MIMasanao IchimataYamaguchi University

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Implication

Randomized trial characterizes immune-cell infiltration and metabolic markers in canine prostate carcinoma, suggesting extensive immune involvement without predictive clinical outcomes.

Key Points

This study aims to characterize immune-cell infiltration and metabolic markers in canine prostate carcinoma and assess their clinical relevance.
Analyzed tumoral tissues from 26 dogs with canine prostate carcinoma and 7 hyperplastic prostate tissues via immunohistochemistry.
Quantitatively assessed five immune cell markers and evaluated various metabolic markers through scoring methods.
Analysed associations between immune cells and survival outcomes using univariate Cox regression.
All tumours exhibited multiple immune-cell subsets with high intertumoral heterogeneity.
Immune-cell densities were higher in canine prostate carcinoma compared to hyperplastic prostate tissue.
No significant associations found between immune-cell density or marker expression and clinical outcomes.

Cite This Study

Kato et al. (2026) studied this question.

synapsesocial.com/papers/6a40ba8861bb0a67205c6624 https://doi.org/10.1016/j.jcpa.2026.05.005

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Implication

Randomized trial characterizes immune-cell infiltration and metabolic markers in canine prostate carcinoma, suggesting extensive immune involvement without predictive clinical outcomes.

Immunohistochemical characterization of immune cell and metabolic markers in canine prostate carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Immunohistochemical characterization of immune cell and metabolic markers in canine prostate carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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