Establishes an Alzheimer's model in zebrafish larvae, suggesting improved assessment of potential therapies.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that impairs cognition and memory. Current protocols for establishing AD models in zebrafish ( Danio rerio ) larvae are limited and lack comprehensive detail. We present a refined zebrafish model, optimizing pH control of AlCl 3 solutions and improving the behavioral assays to ensure a consistent AD-like phenotype. We describe steps for breeding embryos, testing behavior, selecting and treating larvae, and analyzing data. This protocol facilitates high-throughput screening of potential therapeutic drugs and genes for AD.
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Lin et al. (2026) studied this question.
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