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June 28, 2026AntioxidantsOpen Access

Reactive Oxygen and Nitrogen Species in Male Reproductive Health: From Molecular Mechanisms to Clinical Consequences

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Authors

SWS WangChinese University of Hong KongJCJacqueline Pui Wah ChungChinese University of Hong KongDCDavid Yiu Leung ChanChinese University of Hong Kong

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Overview

Review discusses the impact of oxidative stress on male fertility and potential interventions.

Key Points

  • This review aims to explore the role of reactive oxygen and nitrogen species in male reproductive health and their clinical implications.
  • Synthesis of current knowledge on molecular mechanisms by which ROS and RNS affect male reproduction.
  • Discussion of environmental and lifestyle factors influencing ROS and RNS production.
  • Review of clinical implications and antioxidant supplementation strategies.
  • Excessive ROS and RNS impair sperm DNA, proteins, and lipids, affecting motility and fertility.
  • Oxidative stress disrupts the hypothalamic-pituitary-gonadal axis, leading to hormonal imbalances.
  • Antioxidant supplementation shows promise but requires further research for standardized protocols.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a40bab961bb0a67205c674chttps://doi.org/10.3390/antiox15070795
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