What question did this study set out to answer?

Clarify the role of traditional Chinese medicine (TCM) in modern immunometabolic therapy for cancer treatment.

June 28, 2026Chinese MedicineOpen Access

Herb-derived immunometabolic modulators: traditional Chinese medicine at the crossroads of metabolism and antitumor immunity

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Narrative review explores herb-based interventions enhancing antitumor immunity and metabolic adaptation.

Clarify the role of traditional Chinese medicine (TCM) in modern immunometabolic therapy for cancer treatment.
Conducted a narrative review combining ethnopharmacological knowledge and pharmacological studies.
Analyzed TCM-derived interventions with defined metabolic and immune outcomes across various therapeutic axes.
Related findings to classical TCM doctrines and proposed an integrative framework for clinical application.
TCM-derived interventions are positioned along four immunometabolic axes that modulate tumor and immune cell interactions.
Herb-based formulas and compounds attenuate glycolytic flux, induce immunogenic cell death, and enhance immune cell metabolism.
Potential to convert 'cold' tumors to 'hot' lesions, improving responses to existing therapies and treatment tolerance.

Zhang et al. (2026) studied this question.

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