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June 28, 2026Amino AcidsOpen Access

Zinc finger protein-associated gene signature serves as a potential predictor for prognosis and therapeutic response in lung adenocarcinoma

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Authors

MZMi ZouGZGuangda ZhengYBY. M. Bao

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Overview

Retrospective analyses reveal a zinc finger protein gene signature predicts prognosis and immune response in lung adenocarcinoma, indicating therapeutic implications.

Key Points

  • The study aims to evaluate the potential of zinc finger protein-related genes as prognostic indicators and their association with therapeutic responses in lung adenocarcinoma.
  • Conducted retrospective analyses using TCGA and GSE26939 data.
  • Developed a prognostic signature based on differentially expressed zinc finger proteins.
  • Evaluated immune landscape and conducted drug sensitivity analyses.
  • The prognostic signature comprising 12 genes stratified patients into low and high-risk groups, predicting clinical outcomes.
  • Low-risk patients showed higher immune cell infiltration and better responses to immunotherapy.
  • Identified drug candidates included SHP-099, Dimethylfasudil, EMD-534085, and PF-2771.

Cite This Study

Zou et al. (2026) studied this question.

synapsesocial.com/papers/6a40bb1461bb0a67205c6c04https://doi.org/10.1007/s00726-026-03528-y
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  5. 5Immune infiltration-based prognostic signature for molecular subtyping and therapeutic stratification in lung adenocarcinoma2026