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Review reveals the roles of cAMP and its effectors in cellular signaling, indicating significant metabolic implications.
cAMP was the first second messenger to be identified. Its three main effectors are PKA (which phosphorylates numerous metabolic enzymes), EPAC (a guanine-nucleotide-exchange factor), and cyclic-nucleotide-gated ion channels.
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Paolo Sassone‐Corsi (2012) studied this question.
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