Key result
Lipid profile parameters were moderately associated with but not predictive of carotid intima-media thickness (η2 = 0.99-0.24), and did not improve diagnostic sensitivity for atherosclerosis.
Why the study?
To determine whether lipid profile parameters could predict carotid intima-media thickness to improve sonographic diagnostic sensitivity for subclinical atherosclerotic changes.
Do lipid profile parameters predict carotid intima-media thickness in subjects without cardiovascular risk factors?
Observational (n=181)
Do lipid profile parameters predict carotid intima-media thickness in subjects without cardiovascular risk factors?
Effect estimate: η2 = 0.99-0.24
Lipid profiles are moderately associated with but do not predict carotid intima-media thickness, and combining them does not improve the diagnostic sensitivity of sonography for subclinical atherosclerosis screening.
Lipid profiles add no value to CIMT for atherosclerosis screening in low-risk adults; leaves open need for superior noninvasive predictors.
Objective. The purpose of this prospective study was to ascertain if lipid profile parameters could serve as predictors of carotid intima-media thickness (CIMT), which, when combined, may improve the sensitivity of sonographic CIMT measurement in the diagnosis of subclinical atherosclerotic changes. Methods. The lipid profiles and CIMT of 181 subjects without cardiovascular risk factors were measured at the internal, external, common, and bulbar segments. Results. The mean CIMT values obtained were 0.620 ± 0.055 cm for men and 0.575 ± 0.051 cm for women, and the η 2 values (η 2 < 0.04) were used as a measure of association. Across all segments of both carotid arteries, lipid profiles were significantly and moderately associated with but not predictive of CIMT (fasting blood sugar, total cholesterol, and low-density lipoprotein: η 2 = 0.99–0.24). Conclusions. Although lipid profiles were moderately associated with CIMT, they are not significant predictors; hence, combining them with CIMT does not improve the diagnostic sensitivity of sonography in atherosclerosis screening.
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Idigo et al. (2019) conducted an observational in Subclinical atherosclerosis (n=181). Lipid profile parameters was evaluated on Carotid intima-media thickness (CIMT) (η2 = 0.99-0.24). Lipid profile parameters were moderately associated with but not predictive of carotid intima-media thickness (η2 = 0.99-0.24), and did not improve diagnostic sensitivity for atherosclerosis.
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