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Gold commonly occurs in pyrite (FeS2) as "invisible" or refractory gold, as is the case at the giant Lihir (i.e., Ladolam) hybrid alkali-type gold deposit in Papua New Guinea. The Lihir gold deposit is also unique as it the exemplar of a telescoped ore deposit, whereby volcanic sector collapse led to superimposition of shallow-level gold-rich epithermal mineralization upon preexisting, but genetically related, porphyry-style alteration. While this superimposition led to a giant 56 Moz gold resource, it also created complications with regards to ore processing, specifically with regards to the difficulties in mineral processing of the refractory gold-rich pyritic ore.
Sykora et al. (Mon,) studied this question.