Enhanced Hypercoagulability Using Clot Waveform Analysis in Patients with Acute Myocardial Infarction and Acute Cerebral Infarction

Figures

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  Figure 1. CWA-AUC and total ability of CWA-APTT. APTT, activated partial thromboplastin time; navy line, fibrin formation curve; pink line, first derivative curve (velocity); light blue, second derivative curve (acceleration); AUC, area under the curve.

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  Figure 2. Peak times of APTT (A) and sTF/FIXa (B) in HVs, and patients with CLD, cancer, ACI, and AMI. APTT, activated partial thromboplastin time; sTF/FIXa, small amount of tissue factor-induced FIX activation assay; HVs, healthy volunteers; CLD, chronic liver disease; ACI, acute cerebral infarction; AMI, acute myocardial infarction; **, p < 0.01; ***, p < 0.001. Navy line, fibrin formation curve; FF, fibrin formation; pink line, first derivative curve (velocity); first DPH, first derivative peak height; light blue, second derivative curve (acceleration); second DPH, second derivative peak height; solid line, patient; dotted line, control.

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  Figure 3. CWA-APTT (A) and CWA-sTF/FIXa (B) in patients with CLD, cancer, ACI, and AMI. Navy line, fibrin formation curve; FF, fibrin formation; pink line, first-derivative curve (velocity); first DPH, first derivative peak height; light blue, second derivative curve (acceleration); second DPH, second-derivative peak height; solid line, patient; dotted line, control.

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  Figure 4. AUC {(A,B)} AUC/second peak time {(C,D)} of CWA-APTT {(A,C)} and CWA-sTF/FIXa {(B,D)} in HVs and patients with CLD, cancer, ACI, and AMI. APTT, activated partial thromboplastin time; sTF/FIXa, small amount of tissue factor-induced FIX activation assay; HVs, healthy volunteers; CLD, chronic liver disease; ACI, acute cerebral infarction; AMI, acute myocardial infarction; **, p < 0.01; ***, p < 0.001.