Key result
Elastin haploinsufficiency in mice alters the homeostatic set point for arterial mechanical parameters, with structural stiffness increasing with age and significant interactions with sex.
Sex-aging interactions require consideration in vascular mechanics models; leaves open human disease relevance.
A comprehensive study on arterial mechanical behavior as a function of elastin content, aging, and sex in mice. Elastin haploinsufficient arteries start at a different homeostatic set point for mechanical parameters such as circumferential stress, stretch, and material stiffness. Structural stiffness of the arterial wall greatly increases with aging, as expected, but there are interactions between sex and aging for most of the mechanical parameters that are important to consider in future work.
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Hawes et al. (2020) studied Elastin haploinsufficiency. Elastin haploinsufficiency, aging, and sex vs. Wild-type/normal elastin content was evaluated on Arterial mechanical behavior (circumferential stress, stretch, material and structural stiffness). Elastin haploinsufficiency in mice alters the homeostatic set point for arterial mechanical parameters, with structural stiffness increasing with age and significant interactions with sex.
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