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December 3, 2020Frontiers in Cardiovascular MedicineOpen Access

Systematic Pharmacology and GEO Database Mining Revealed the Therapeutic Mechanism of Xuefu Zhuyu Decoration for Atherosclerosis Cardiovascular Disease

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Key result

Quercetin, an effective component of Xuefu Zhuyu decoration, significantly reduced LPS-induced expression of VCAM-1, ICAM-1, and pro-inflammatory cytokines in human umbilical vein endothelial cells, impeding monocyte attachment.

Why the study?

Xuefu Zhuyu decoration has been used to treat ASCVD, but its effective compounds and underlying molecular mechanisms remain promiscuous, limiting its clinical application.

Population

Human umbilical vein endothelial cells in vitro model and public databases

Comparison

Xuefu Zhuyu decoration components vs controls

Design

Systematic pharmacology, database mining, and in vitro experimental study

Authors

BLBin LiangYXYang XiangXZXiaokang Zhang

Discussion

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Overview

XFZYD targets in ASCVD require experimental validation; leaves open clinical translation pending prospective trials.

Structured PICO

P
Population
In vitro and in silico study investigating the therapeutic mechanism of Xuefu Zhuyu decoration and its effective component quercetin on human umbilical vein endothelial cells.
I
Intervention
Quercetin (25, 50 µM) and bioinformatics analysis of Xuefu Zhuyu decoration (XFZYD)
C
Comparator
LPS alone, celecoxib (PTGS2 inhibitor 10 µM), and rebamipide (PTGS2 agonist 100 nM)
O
Outcome
Expression of VCAM-1, ICAM-1, and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), and adhesion of HUVECs with monocytessurrogate

Main Result

p-value: p=<0.0001

Quercetin, an effective component of Xuefu Zhuyu decoration, protects endothelial cells by reducing inflammatory responses and monocyte adhesion, potentially targeting PTGS2.

Limitations

  • The mechanism predicted of XFZYD in treating atherosclerosis still needs to be supplemented by in vivo and in vitro experiments.
  • Verified only one effective component in vitro, and the other effective components still needed to be confirmed experimentally.
  • Pathological development of atherosclerosis involves complex processes requiring further in vivo and in vitro experiments
  • Only one effective component was verified in vitro

Cite This Study

Liang et al. (2020) studied Atherosclerosis cardiovascular disease. Quercetin (effective component of Xuefu Zhuyu decoration) vs. LPS alone was evaluated on LPS-induced attachment of monocytes to HUVECs and expression of VCAM-1, ICAM-1, and pro-inflammatory cytokines (p=<0.0001). Quercetin, an effective component of Xuefu Zhuyu decoration, significantly reduced LPS-induced expression of VCAM-1, ICAM-1, and pro-inflammatory cytokines in human umbilical vein endothelial cells, impeding monocyte attachment.

synapsesocial.com/papers/6a41c9eaf24e98555fcd22b8https://doi.org/10.3389/fcvm.2020.592201
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chinese patent medicine Xuefu Zhuyu capsule for the treatment of unstable angina pectoris: A systematic review of randomized controlled trials2014 · 34 citations
  2. 2The Effects of Xuefu Zhuyu and Shengmai on the Evolution of Syndromes and Inflammatory Markers in Patients with Unstable Angina Pectoris after Percutaneous Coronary Intervention: A Randomised Controlled Clinical Trial2013 · 21 citations
  3. 3Thrombosis formation on atherosclerotic lesions and plaque rupture2014 · 698 citations
  4. 4Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice2012 · 266 citations
  5. 5Systematic Pharmacology and GEO Database Mining Revealed the Mechanism of XFZYD Therapy for ASCVD2020 · 1 citations