Key result
Erectile dysfunction linked to ~48% higher risk of CVD, CHD, stroke, and all-cause mortality.
Why the study?
Observational studies suggest an association between erectile dysfunction and CVD incidence, but whether erectile dysfunction is an independent risk factor remains controversial.
Does erectile dysfunction increase the risk of cardiovascular disease and all-cause mortality in men?
Comparison
Men with erectile dysfunction vs reference group
Design
Meta-analysis of prospective cohort studies
Authors
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Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“In the analysis by Dong et al including 12 prospective cohort studies involving 36 744 participants, it was suggested that ED independent of other risk factors significantly increased the risk of CVD, coronary artery disease, stroke, and all-cause mortality.”
“Our results reveal that erectile dysfunction is, in and of itself, a potent predictor of cardiovascular risk. Our findings suggest that clinicians should perform further targeted screening in men with erectile dysfunction, regardless of other cardiac risk factors and should consider managing any other risk factors -- such as high blood pressure or cholesterol -- that much more aggressively.”
“Health care providers should consider including ED as a component of assessing cardiovascular risk among middle-aged men. While there are effective treatments for ED, one must never overlook an opportunity to ask a simple question: 'Why?' In addition, men should be aware of the potential implications of ED and inform their provider.”
ED signals higher CVD and mortality risk independent of conventional factors; hypothesis-generating for screening or intervention trials.
Meta-Analysis (n=36,744)
Does erectile dysfunction increase the risk of cardiovascular disease and all-cause mortality in men?
Relative Risk: 1.48 (95% CI 1.25–1.74)
This meta-analysis demonstrates that erectile dysfunction is significantly associated with an increased risk of cardiovascular disease and all-cause mortality, independent of conventional cardiovascular risk factors.
Dong et al. (2011) conducted a meta-analysis in Cardiovascular disease (n=36,744). Erectile dysfunction vs. Reference group (men without erectile dysfunction) was evaluated on Cardiovascular disease (CVD) (RR 1.48, 95% CI 1.25 to 1.74). Erectile dysfunction significantly increased the risk of cardiovascular disease (RR 1.48; 95% CI 1.25-1.74), coronary heart disease, stroke, and all-cause mortality.
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