What is the clinical evidence from this study?

Study design: Review. Population: Stable ischemic heart disease. Intervention: Stress Cardiac Magnetic Resonance (CMR) vs. SPECT.

What question did this study set out to answer?

To evaluate the clinical utility of stress cardiac magnetic resonance (CMR) imaging in assessing myocardial ischemia and function.

June 29, 2026Journal of the American College of CardiologyOpen Access

Stress Cardiac Magnetic Resonance Myocardial Perfusion Imaging

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Key result

Stress CMR offers superior diagnostic sensitivity over SPECT for detecting angiographically significant CAD.

Why the study?

Does Stress CMR improve diagnostic sensitivity in detecting angiographically significant coronary artery disease compared to SPECT in patients with suspected stable ischemic heart disease?

Population

Patients with moderate to high pre-test probability of having stable ischemic heart disease, and patients…

Comparison

Stress Cardiac Magnetic Resonance Myocardial… vs SPECT (Single-photon emission computed tomography)

Design

Review

Authors

APAmit R. PatelGeneral Cardiology MSMichael SalernoGeneral Cardiology RKRaymond Y. KwongCardiac Imaging

Discussion

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Implication

Stress CMR is a highly sensitive, radiation-free imaging modality that is particularly valuable for evaluating ischemia and viability in patients with moderate to high pre-test probability of stable ischemic heart disease.

Key Points

To evaluate the clinical utility of stress cardiac magnetic resonance (CMR) imaging in assessing myocardial ischemia and function.
Reviewed literature including randomized-controlled trials validating stress CMR performance.
Analyzed data on diagnostic sensitivity and risk stratification capabilities of stress CMR.
Assessed the value of myocardial blood flow quantification during stress CMR.
Stress CMR demonstrated higher diagnostic sensitivity than SPECT for detecting significant coronary artery disease.
Valuable for patients with a moderate to high pre-test probability of stable ischemic heart disease.
Effectively evaluates challenging cases such as women and individuals with prior revascularization.

Structured PICO

Does Stress CMR improve diagnostic sensitivity in detecting angiographically significant coronary artery disease compared to SPECT in patients with suspected stable ischemic heart disease?

Population

Patients with moderate to high pre-test probability of having stable ischemic heart disease, and patients with challenging imaging characteristics such as women, individuals with prior revascularization, and left ventricular dysfunction

Exposure

Stress Cardiac Magnetic Resonance (CMR) Myocardial Perfusion Imaging

Comparator

SPECT (Single-photon emission computed tomography)

Outcome

Diagnostic sensitivity in detecting angiographically significant coronary artery diseasesurrogate

Cite This Study

Patel et al. (2021) conducted a review in Stable ischemic heart disease. Stress Cardiac Magnetic Resonance (CMR) vs. SPECT was evaluated. Stress cardiac magnetic resonance imaging is a valuable, non-invasive tool with higher diagnostic sensitivity than SPECT for detecting angiographically significant coronary artery disease.

synapsesocial.com/papers/6a41e434d8bc5ceb756acc12 https://doi.org/10.1016/j.jacc.2021.08.022

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Stress Cardiac Magnetic Resonance Myocardial Perfusion Imaging

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Stress Cardiac Magnetic Resonance Myocardial Perfusion Imaging

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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