Randomized trial demonstrates IL-6 expression in renal tissue of chickens infected with IBV, suggesting nephropathogenicity.
The gamma coronavirus that causes extremely contagious disease in chickens is based on the avian infectious bronchitis virus. The respiratory tract, proventriculus, cecal tonsils, oviduct, and kidney are among the virus's preferred host tissues. Young chickens with infections typically experience respiratory distress. The virus causes respiratory distress in broiler chickens, but certain strains can induce interstitial nephritis. This study was performed to analyses and detect the expression of the pro-inflammatory cytokine (IL-6) (Interleukin-6) in the kidney tissue infected with IBV (Infectious Bronchitis Virus) by using the Immunohistochemistry detection technique. The samples were taken from the kidney of chicken infected with IBV, the results of the study revealed positive expression of (IL-6), most of this expression was in the epithelial cells of the renal tubules in the cortex area compared to the negative expression of (IL-6) in the control group. We concluded that the IBV strain in Basrah province has cell tropism to renal tissues and has nephropathogenic property causing nephritis.
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Najlaa Hameed Megdad (2026) studied this question.
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