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June 29, 2026NeurologyOpen Access

Incidental DWI-Positive Lesions in 2 Cohorts of CAA and CADASIL

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Authors

ATAnnemieke ter TelgteAKAnna M. de KortADAnna Dewenter

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Overview

Randomized trial reports the prevalence of incidental DWI-positive lesions in CAA and CADASIL, suggesting distinct biomarker associations.

Key Points

  • This study aims to describe the prevalence and associations of incidental DWI-positive lesions in two types of cerebral small vessel disease.
  • Data from two hospital-based prospective cohorts in the Netherlands and Germany involving CAA and CADASIL patients were analyzed.
  • 3T high-resolution MRIs were performed, and incidental DWI-positive lesions were assessed alongside cardiovascular risk factors and biomarker associations.
  • Incidental DWI-positive lesions were found in 56% of CAA patients and 21% of CADASIL patients.
  • In CAA, 65% of lesions were cortical, while in CADASIL, 95% were located in subcortical white or gray matter.
  • DWI-positive lesions in CAA correlated with increased serum and CSF neurofilament light chain levels, whereas in CADASIL, they were linked to high serum neurofilament light chain and increased white matter hyperintensity volume.

Cite This Study

Telgte et al. (2026) studied this question.

synapsesocial.com/papers/6a420ab2f91bb43ea9191ed2https://doi.org/10.1212/wnl.0000000000218160
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