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Characteristics and clinical correlates of objective medication adherence in older adults with cognitive impairment

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Randomized trial examines medication adherence correlates in older adults with cognitive impairment, suggesting monitoring needs.

The study aims to explore the clinical correlates of objective medication adherence in older adults with cognitive impairment.
Eighty-three older adults with neurocognitive disorders were monitored for medication adherence via pill counts and MEMS for two months.
MEMS analysis focused on 65 Consistent Users, analyzing cognitive domains and medication management abilities as correlates.
Cognitive performance in Attention/Processing Speed, Executive Functioning, and Memory was evaluated alongside self-reported strategies.
46% demonstrated ≤90% pill count adherence, with 16% showing <80%; 39% had ≤90% MEMS adherence with 23% <80%.
Inconsistent MEMS Users had poorer Memory performance, indicating memory impacted device integration more than medication-taking behavior.
Only Medication Management Ability Assessment performance uniquely predicted adherence classification, with some compensatory strategies unlinked to overall adherence.

Margolis et al. (2026) studied this question.

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