What question did this study set out to answer?

This review aims to compare the efficacy and safety of oral ivermectin and topical permethrin for treating classic scabies.

Comparative efficacy and safety of oral ivermectin, topical permethrin, and combination in the treatment of patients with classic scabies: systematic review and network meta-analysis

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Systematic review evaluates efficacy, safety of ivermectin and permethrin treatments in classic scabies, suggesting implications for practice.

This review aims to compare the efficacy and safety of oral ivermectin and topical permethrin for treating classic scabies.
Conducted systematic review and network meta-analysis of randomized controlled trials from databases like MEDLINE and CENTRAL.
Included data from 38 RCTs with a total of 4879 patients; assessed clinical cure and serious adverse events.
Utilized random-effects model for network meta-analysis and evaluated risk of bias using Cochrane Risk of Bias 2.0.
Oral ivermectin showed little difference in clinical cure rates compared to permethrin (network RR 0.95, 95% CI [0.89, 1.02]).
Serious adverse events were rare (1 case in 3212, 0.03%; very low certainty evidence).
Combination therapy of oral ivermectin and permethrin suggested potential effectiveness over permethrin alone (network RR 1.21, 95% CI [0.94, 1.56]).

Genuino et al. (2026) studied this question.

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Systematic review evaluates efficacy, safety of ivermectin and permethrin treatments in classic scabies, suggesting implications for practice.