December 1, 2008Current Pharmaceutical Design
The Triad: Erectile Dysfunction - Endothelial Dysfunction - Cardiovascular Disease
Key result
Erectile dysfunction serves as an early clinical manifestation of generalized vascular disease and an independent risk factor for future cardiovascular events due to underlying endothelial dysfunction.
Population
Men with erectile dysfunction and/or coronary artery disease
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
ED may flag early vascular disease in practice; extends endothelial links but leaves open prospective screening trials.
Structured PICO
P
Population
Men with erectile dysfunction and/or coronary artery disease
I
Intervention
Lifestyle and risk factor modification, and pharmacologic therapy (phosphodiesterase type-5 inhibitors and non-ED-targeting drugs)
Erectile dysfunction serves as a clinical barometer for cardiovascular disease, providing a unique opportunity for early preventive vascular health interventions in men.
Cite This Study
Vlachopoulos et al. (2008) conducted a review in Erectile dysfunction and cardiovascular disease. Erectile dysfunction serves as an early clinical manifestation of generalized vascular disease and an independent risk factor for future cardiovascular events due to underlying endothelial dysfunction.