Key result
Aortic wall 12 years post-Nikaidoh operation exhibits severe structural deterioration and elastin loss.
Why the study?
The pathophysiology of structural and functional changes in the aortic root following the Nikaidoh operation and their potential for reversibility have not been studied.
Case Report (n=4)
Yes
The Nikaidoh operation can lead to severe structural abnormalities in the aortic wall over time, including loss of elastin and smooth muscle deterioration, which may have major clinical implications for long-term homeostasis.
May warrant aortic surveillance post-Nikaidoh; leaves open reversibility and need for prospective studies.
The Nikaidoh operation continues to be used for patients with transposition of the great arteries, ventricular septal defect and left ventricular outflow tract obstruction. We recently reported structural and functional changes in the aortic root during the follow-up of a patient who underwent the Nikaidoh operation. These changes necessitated re-operation. The pathophysiology of these changes and their potential for reversibility have not yet been studied. In this communication, we describe the extensive structural changes in the aortic wall of the same patient.
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Yacoub et al. (2023) conducted a case report in Transposition of the great arteries post-Nikaidoh operation (n=4). Nikaidoh operation vs. Normal aortic wall specimens was evaluated on Structural, extracellular matrix, and cellular changes in the aortic wall. The aortic wall 12 years post-Nikaidoh operation exhibited severe structural deterioration, loss of elastin, and reduced smooth muscle proteins, alongside signs of healing like innervation.
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