Degenerative aortic stenosis is a common valvular lesion affecting 2-7% of the population over 65 years of age, with calcification of a normal trileaflet valve being the most common cause.
Provides a comprehensive overview of the diagnosis and management of degenerative aortic stenosis.
#### Summary points Aortic stenosis is the most common valvular lesion in Europe and North America. It primarily presents as calcific aortic stenosis in 2-7% of the population aged >65 years.1 About 80% of adult patients with symptomatic aortic stenosis are male. As 1-2% of the population is born with a congenital bicuspid aortic valve and populations are ageing, aortic stenosis is becoming more common. By 2020, about 3.5 million people in England are expected to have aortic sclerosis and 150 000 will have severe aortic stenosis.2 Here we provide an overview to help diagnosis and a summary of the management of AS and its sequelae. Many of the points made in this review are based on randomised controlled trials. However, observational studies and the guideline recommendations of the American Heart Association and the American College of Cardiology and of the European Society of Cardiology are also included to provide comprehensive overviews that are beyond the scope of this article. The most common cause of aortic stenosis in adults is calcification of a normal trileaflet (fig 1⇓). Calcific aortic stenosis is thought to be a degenerative process that shares many features with coronary artery disease, such as lipid accumulation, …
Ramaraj et al. (Thu,) conducted a review in Aortic stenosis. Degenerative aortic stenosis is a common valvular lesion affecting 2-7% of the population over 65 years of age, with calcification of a normal trileaflet valve being the most common cause.