September 27, 2013Journal of Cardiovascular Pharmacology
The Immune System and the Remodeling Infarcted Heart
Key result
Overactive immune responses following myocardial infarction accentuate dilative remodeling and may be associated with chamber dilation, systolic dysfunction, and heart failure.
Population
Patients surviving a myocardial infarction and experimental models of myocardial infarction
Design
Review
Authors
Discussion
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Implication
Anti-inflammatory targeting may limit post-MI remodeling and dysfunction; extends RCT evidence on immune modulation in cardiac repair.
Structured PICO
P
Population
Patients surviving a myocardial infarction and experimental models of myocardial infarction
The immune system plays a critical role in both the repair of the infarcted heart and adverse ventricular remodeling, highlighting the potential for targeted anti-inflammatory interventions.
Cite This Study
Nikolaos G. Frangogiannis (2013) conducted a review in Myocardial infarction. Immune system response was evaluated. Overactive immune responses following myocardial infarction accentuate dilative remodeling and may be associated with chamber dilation, systolic dysfunction, and heart failure.