Key result
By 1959, 83% of patients with isolated mitral stenosis under medical treatment had died, and the majority of survivors showed signs of disease progression.
Cohort (n=271)
The natural history of medically treated symptomatic isolated mitral stenosis is characterized by extremely high long-term mortality (83%) and disease progression among survivors.
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Historical cohort underscores poor prognosis of medically managed mitral stenosis; leaves open impact of contemporary interventions on long-term survival.
This report is a follow-up of 271 patients with isolated mitral stenosis under medical treatment. The material comprises patients who came under medical care for cardiac symptoms during the years 1933-49. A first report of this series has already been published (Olesen, 1955). By 1959, 83 per cent of the patients had died, and the majority of survivors showed symptoms and signs of progression of the disease. On this background an analysis of the last follow-up data is presented as a contribution to the description of the natural history of mitral stenosis.
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Knud H. Olesen (1962) conducted a cohort in Isolated mitral stenosis (n=271). Medical treatment was evaluated on Death. By 1959, 83% of patients with isolated mitral stenosis under medical treatment had died, and the majority of survivors showed signs of disease progression.
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