Key result
The autonomic neurohumoral system influences cardiovascular morbidity and mortality by modulating the innate and adaptive immune systems, offering new perspectives on therapeutic interventions.
Highlights the role of the autonomic nervous system in modulating immune responses and end-organ damage in cardiovascular diseases like heart failure and hypertension.
May influence HF progression via autonomic-immune crosstalk; leaves open whether targeting these pathways improves outcomes.
The autonomic nervous system is a powerful regulator of circulatory adjustments to acute hemodynamic stresses. Here we focus on new concepts that emphasize the chronic influence of the sympathetic and parasympathetic systems on cardiovascular pathology. The autonomic neurohumoral system can dramatically influence morbidity and mortality from cardiovascular disease through newly discovered influences on the innate and adaptive immune systems. Specifically, the end-organ damage in heart failure or hypertension may be worsened or alleviated by pro- or anti-inflammatory pathways of the immune system, respectively, that are activated through neurohumoral transmitters. These concepts provide a major new perspective on potentially life-saving therapeutic interventions in the deadliest of diseases.
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Abboud et al. (2017) conducted a review in Cardiovascular diseases. Autonomic regulation of the immune system was evaluated. The autonomic neurohumoral system influences cardiovascular morbidity and mortality by modulating the innate and adaptive immune systems, offering new perspectives on therapeutic interventions.
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