Key result
Paclitaxel-coated balloon angioplasty linked to adverse remodeling and coronary artery aneurysms in 4 cases.
Why the study?
Paclitaxel-coated balloons may cause adverse remodelling resulting in coronary artery aneurysm in some cases.
Does paclitaxel-coated balloon angioplasty cause coronary artery aneurysm?
Case Report (n=4)
Does paclitaxel-coated balloon angioplasty cause coronary artery aneurysm?
Paclitaxel-coated balloons may cause adverse remodeling resulting in coronary artery aneurysms.
May warrant vigilance for aneurysms after paclitaxel-coated balloon use; leaves open true incidence and causality for prospective study.
Drug-coated balloons have emerged as effective therapy for treating in-stent restenosis and de novo lesions. The animal studies have shown the mechanism of action of paclitaxel-coated balloon in coronary arteries which leads to medial necrosis that may explain the better angiographic remodelling observed with paclitaxel- as compared to sirolimus-coated balloons. However, in some cases, paclitaxel may cause adverse remodelling resulting in coronary artery aneurysm. Here, we report 4 cases of coronary artery aneurysm post paclitaxel-coated balloon angioplasty and discuss its possible mechanism, management, and potential implications for future practice.
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Saboe et al. (2025) conducted a case report in Coronary artery aneurysm (n=4). Paclitaxel-coated balloon angioplasty was evaluated on Coronary artery aneurysm. Paclitaxel-coated balloon angioplasty can lead to adverse remodeling and coronary artery aneurysm, as detailed in 4 reported cases.
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