What question did this study set out to answer?

The aim is to explore the unique structural features of G-quadruplexes and their multifaceted roles in transcriptional regulation and genome organization.

June 30, 2026Current Opinion in Chemical BiologyOpen Access

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation

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Authors

SNSabrina Pia NuccioImperial College London MSMichele StasiImperial College London ECEnrico CadoniGhent University

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Implication

This review examines G-quadruplexes’ structural uniqueness and their role in transcriptional regulation, suggesting implications for genome architecture.

Key Points

The aim is to explore the unique structural features of G-quadruplexes and their multifaceted roles in transcriptional regulation and genome organization.
Review of recent literature on G-quadruplexes and their interactions with chromatin.
Discussion of methodological advances such as small molecule stabilizers and CRISPR technology.
Integration of findings related to G-quadruplex structure and function in transcriptional contexts.
G-quadruplexes influence key regulatory processes including nucleosome occupancy and chromatin interactions.
Evidence shows G-quadruplexes can modulate biomolecular condensate formation related to transcription.
Potential therapeutic targeting of G-quadruplexes could impact transcriptional regulation.

Cite This Study

Nuccio et al. (2026) studied this question.

synapsesocial.com/papers/6a435c08759b888809a5294b https://doi.org/10.1016/j.cbpa.2026.102718

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Implication

This review examines G-quadruplexes’ structural uniqueness and their role in transcriptional regulation, suggesting implications for genome architecture.

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation

Discussion

Member takes

Implication

Key Points

Cite This Study

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation

Discussion

Member takes

Implication

Key Points

Cite This Study

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