Key result
Larger atrial septal fatty deposits are linked to a ~76% higher frequency of atrial arrhythmias.
Why the study?
A relation between large adipose tissue deposits in the atrial septum (lipomatous hypertrophy) and atrial arrhythmias had been suggested, prompting examination of their morphologic features and clinical significance.
Population
91 patients with massive fatty deposits in the atrial septum, focusing primarily on 80 patients
Design
Observational study
Authors
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May warrant arrhythmia surveillance in severe lipomatous hypertrophy; hypothesis-generating and needs prospective confirmation before practice change.
Observational (n=80)
Absolute Event Rate: 60% vs 34%
p-value: p=<0.01
Massive fatty deposits in the atrial septum are associated with increased epicardial fat, atherosclerotic coronary artery disease, and a higher frequency of atrial arrhythmias.
Shirani et al. (1993) conducted an observational in Massive fatty deposits in the atrial septum (lipomatous hypertrophy) (n=80). Larger deposits of fat (atrial septal thickness ≥3 cm) vs. Smaller deposits of fat (atrial septal thickness <3 cm) was evaluated on Atrial arrhythmias (p=<0.01). Larger fatty deposits in the atrial septum (≥3 cm) were associated with a significantly higher frequency of atrial arrhythmias compared to smaller deposits (60% vs. 34%, p<0.01).
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