Key result
Serial 1-hour sampling shows no difference in cardiac biomarkers or platelet indices during acute STEMI.
Why the study?
New biomarkers are being sought to better predict CVD risk, prompting an investigation into platelet indices and biochemical variability during the first day after hospital admission for acute myocardial infarction.
Observational (n=73)
No
In patients with acute STEMI, platelet count and mean platelet volume show a negative correlation within 24 hours of admission, but do not significantly change over a 1-hour interval.
Stable biomarkers over 1 hour support flexible sampling timing in acute STEMI; confirms short-term reproducibility of cardiac and platelet indices.
Introduction: Cardiovascular diseases (CVD) are responsible for approximately 17.9 millions of deaths every year, with a higher impact on low and middle-income populations. Despite traditional risk factors, asymptomatic individuals with atherosclerosis have been identified, and new biomarkers are being sought to better predict CVD risk. This study aims to investigate the relationship between platelets indices and biochemical variability in the first day after patient admission in the hospital. Methods: A pilot study was conducted to analyze 73 medical records of patients who experienced acute myocardial infarction, to analyze the association among mean platelet volume (MPV), platelet count (PC), creatine phosphokinase (CPK), creatine phosphokinase-MB (CKMB) and ultra-sensitive cardiac troponin I (TnI-us) between the first and second sampling (1-hour intervals), to investigate acute ST-segment elevation myocardial infarction. Results and conclusion: The biochemical analysis showed no significant difference in CPK CK MB, TnI-us, MPV and PC levels between the first and second samples. A negative correlation between PC and MPV and a moderate negative correlation between PC and CPK were found in our AMI patients within 24 hours of hospital admission.
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Torres et al. (2023) conducted an observational in Acute ST-elevation myocardial infarction (STEMI) (n=73). 1-hour time interval after hospital admission vs. Baseline (first sample) was evaluated on Mean platelet volume (MPV) at 1-hour interval (p=0.97). In patients with acute ST-elevation myocardial infarction, there were no significant differences in cardiac biomarkers or platelet indices between samples taken 1 hour apart, though a negative correlation was observed between platelet count and mean platelet volume.
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