Key result
Nebulin SH3 binds to proline-rich peptides PR2 of titin and myopalladin MyoP2 with micromolar affinity (31 and 3.4 microM, respectively), suggesting a role in sarcomere assembly.
Population
6 proline-rich peptides derived from the 28-mer PEVK modules of titin and the Z-line protein myopalladin
Design
Preclinical
Authors
Loading...
Hypothesis-generating for sarcomere regulation; leaves open relevance to titin-related cardiac disease.
Titin PEVK and myopalladin bind to nebulin SH3 with micromolar affinity, suggesting they play signaling roles in targeting and orientating nebulin to the Z-line during sarcomere assembly.
Ma et al. (2002) studied this question. Nebulin SH3 domain was evaluated on Binding affinity to proline-rich peptides. Nebulin SH3 binds to proline-rich peptides PR2 of titin and myopalladin MyoP2 with micromolar affinity (31 and 3.4 microM, respectively), suggesting a role in sarcomere assembly.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: