Nebulin as a length regulator of thin filaments of vertebrate skeletal muscles: correlation of thin filament length, nebulin size, and epitope profile.
Key result
Nebulin size variants showed a positive linear correlation with thin filament length in skeletal muscles, suggesting nebulin acts as an inextensible length-regulating template.
Population
Vertebrate skeletal muscles (including rabbit nebulin purified for mAb production)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports nebulin as thin-filament length template; leaves open coextensiveness in vivo.
Structured PICO
P
Population
Vertebrate skeletal muscles (including rabbit nebulin purified for mAb production)
E
Exposure
Immunoelectron microscopic studies mapping epitope profiles of nebulin variants and gelsolin treatment
O
Outcome
Correlation between the size of nebulin variants and the length distribution of thin filaments
Nebulin acts as an inextensible full-length molecular filament that is coextensive with thin filaments in skeletal muscles, serving as a length-regulating template.
Cite This Study
Krüger et al. (1991) studied this question. Immunoelectron microscopic mapping of nebulin was evaluated on Correlation between nebulin size variants and thin filament length distribution. Nebulin size variants showed a positive linear correlation with thin filament length in skeletal muscles, suggesting nebulin acts as an inextensible length-regulating template.