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December 11, 2018Frontiers in GeneticsOpen Access

Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals

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Authors

PKParfait KezimanaADAlexey A. DmitrievAKAnna V. Kudryavtseva

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Overview

Review highlights the biosynthesis of secoisolariciresinol diglucoside and its health benefits, suggesting new nutraceutical flaxseed cultivars.

Key Points

  • This review aims to explore the biosynthesis of secoisolariciresinol diglucoside (SDG) and its health benefits in flaxseed.
  • Review of existing studies on SDG and its metabolites
  • Focus on biosynthetic pathways and involved genes
  • Analysis of health benefits associated with SDG and mammalian lignans
  • SDG demonstrates protective effects against cardiovascular diseases, diabetes, and cancer.
  • Mammalian lignans enterodiol and enterolactone also show promising anti-cancer effects.
  • Insights into glycosylation genes could aid in developing new flaxseed cultivars rich in beneficial lignans.

Cite This Study

Kezimana et al. (2018) studied this question.

synapsesocial.com/papers/6a445cb57dc089af01a440f8https://doi.org/10.3389/fgene.2018.00641
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antithrombic and anti-atherogenic effects of partially defatted flaxseed meal using a laser-induced thrombosis test in apolipoprotein E and low-density lipoprotein receptor deficient mice2003 · 22 citations
  2. 2THERAPEUTIC POTENTIAL OF SECOISOLARICIRESINOL DIGLUCOSIDE: A PLANT LIGNAN2012 · 19 citations
  3. 3Single amino acid mutations of <i>Medicago</i> glycosyltransferase UGT85H2 enhance activity and impart reversibility2009 · 43 citations
  4. 4UGT74S1 is the key player in controlling secoisolariciresinol diglucoside (SDG) formation in flax2017 · 28 citations
  5. 5Dietary Lignans: Potential Role in Cancer Prevention2005 · 164 citations