Key result
Hypokalemia at discharge was independently associated with a higher risk of 2-year cardiac death in patients with HFrEF (HR 2.60; 95% CI 1.20-5.64).
Why the study?
Although dyskalemia is associated with poor prognosis in heart failure, the different prognostic impacts of hypokalemia and hyperkalemia remain vastly unclear.
Does dyskalemia at discharge affect long-term mortality in hospitalized patients with heart failure?
Population
3398 patients hospitalized for HF
Comparison
Hypokalemia (<3.5 mEq/L) vs normokalemia (3.5−5.0 mEq/L) vs hyperkalemia (≥5.0 mEq/L) at discharge
Design
Multicenter study
Follow-up
Two-year
Authors
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Discharge hypokalemia signals higher cardiac death risk in HFrEF; leaves open whether correction improves outcomes.
Cohort (n=3,398)
Yes
Does dyskalemia at discharge affect long-term mortality in hospitalized patients with heart failure?
Hazard Ratio: 2.6 (95% CI 1.2–5.64)
Hypokalemia at discharge is independently associated with increased 2-year cardiac death in patients with HFrEF, whereas hyperkalemia is not.
Miura et al. (2022) conducted a cohort in Heart failure (n=3,398). Hypokalemia (<3.5 mEq/L) at discharge vs. Normokalemia (3.5-5.0 mEq/L) was evaluated on 2-year cardiac death in HFrEF (LVEF < 40%) (HR 2.60, 95% CI 1.20-5.64). Hypokalemia at discharge was independently associated with a higher risk of 2-year cardiac death in patients with HFrEF (HR 2.60; 95% CI 1.20-5.64).
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