Key result
Baseline myocardial TLR4 expression (grading ≥2) predicted a positive response to immunosuppressive therapy with 100% sensitivity and 90.9% specificity.
Why the study?
Does myocardial TLR4 expression predict response to immunosuppressive therapy in patients with virus-negative chronic inflammatory cardiomyopathy?
Population
237 patients with virus-negative inflammatory cardiomyopathy treated with immunosuppression
Comparison
Myocardial expression of Toll-like receptor 4… vs Patients with low or no TLR4 expression
Design
Cohort
Follow-up
6 months
Authors
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TLR4 2+ may identify immunosuppression responders in inflammatory cardiomyopathy; leaves open prospective validation before clinical adoption.
Cohort (n=237)
Does myocardial TLR4 expression predict response to immunosuppressive therapy in patients with virus-negative chronic inflammatory cardiomyopathy?
p-value: p=<0.001
Myocardial TLR4 expression is a highly sensitive and specific biomarker for predicting positive response to immunosuppressive therapy in virus-negative inflammatory cardiomyopathy.
Chimenti et al. (2017) conducted a cohort in Virus-negative chronic inflammatory cardiomyopathy (n=237). Myocardial expression of Toll-like receptor 4 (TLR4) vs. Low or no TLR4 expression was evaluated on Response to immunosuppressive therapy (p=<0.001). Baseline myocardial TLR4 expression (grading ≥2) predicted a positive response to immunosuppressive therapy with 100% sensitivity and 90.9% specificity.
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