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July 1, 2026Open Access

Method Development and Validatio for Simultaneous Estimation of Ceftazidime and Avibactam in Pharmaceutical Dosage Form by Uv Visible Spectrophotometric Method

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Authors

MRMrs. N. Sandhyarani*, Dilshad Begum, B. Kavya, Sumaiya Begum, K. Anusha, D. Mayuri Ramulu

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Overview

Randomized trial demonstrates an accurate estimation of ceftazidime and avibactam in pharmaceutical forms, indicating potential for quality control.

Key Points

  • The aim was to develop and validate a UV spectrophotometric method for estimating ceftazidime and avibactam in pharmaceutical dosage forms.
  • Ceftazidime and Avibactam were analyzed using a UV-Vis spectrophotometer at 257nm and 226nm, respectively.
  • Validation included evaluating linearity, accuracy, precision, sensitivity, limit of detection (LOD), and limit of quantification (LOQ).
  • Linearity was established over a concentration range of 2-20 µg/mL with a regression coefficient of 0.987.
  • Percentage recovery ranged from 98.7% to 101% during accuracy assessments.
  • Limits of detection were 6.2215 µg/mL for ceftazidime and 6.23771 µg/mL for avibactam.
  • The method demonstrated satisfactory reproducibility with %RSD values less than 2%.

Cite This Study

Mrs. N. Sandhyarani*, Dilshad Begum, B. Kavya, Sumaiya Begum, K. Anusha, D. Mayuri Ramulu (2026) studied this question.

synapsesocial.com/papers/6a44ad765cd2549c8bc43011https://doi.org/10.5281/zenodo.20963887
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