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July 1, 2026Scientific ReportsOpen Access

Maternal Western diet alters milk leptin levels and early postnatal leptin handling in rat offspring

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Authors

PBPere BibiloniRMRita De MatteisJSJuana Sánchez

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Overview

Randomized trial evaluates maternal Western diet effects on leptin in rat offspring, suggesting altered metabolic programming.

Key Points

  • This research assesses how a maternal Western diet impacts the levels of leptin and associated miRNAs in breast milk and their absorption in offspring.
  • Female rats fed a control or Western diet before and during gestation and lactation.
  • Dams and pups were euthanized at postnatal day 4 for analysis of leptin levels and gastric content.
  • Gastric leptin signal was evaluated using immunohistochemistry.
  • WD-Dams showed significantly higher milk leptin levels (1.6 ± 0.46 ng/mL) compared to C-Dams (1.0 ± 0.33 ng/mL, p = 0.012).
  • Despite increased milk leptin, WD-pups did not show a corresponding increase in gastric leptin content or circulating levels.
  • MiR-17 levels were higher in WD-milk, indicating a potential link with duodenal levels in WD-pups.

Cite This Study

Bibiloni et al. (2026) studied this question.

synapsesocial.com/papers/6a44add75cd2549c8bc4340fhttps://doi.org/10.1038/s41598-026-58382-5
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Also Consider

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  1. 1Metabolomic Insights Into the Impact of a Maternal Western‐Style Diet and Leptin Supplementation During Suckling on Adult Rat Offspring2026
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  4. 4The Effect of Maternal Overweight/Obesity on Serum and Breastmilk Leptin, and Its Associations with Body Composition, Cardiometabolic Health Indices, and Maternal Diet: The BLOOM Study2024 · 4 citations
  5. 5The Investigation of The Metabolic Effect of High Salt or Western Diet During Pregnancy and Lactation on Rat Dams and Postnatal Offspring Rats2024