What question did this study set out to answer?

The study aims to evaluate whether the CD38 inhibitor 78c can enhance NAD+ levels and mitigate bone loss in periodontitis-affected mice.

Inhibition of CD38 by 78c Enhanced NAD+ and Alleviated Alveolar Bone Loss in Mice with Experimental Periodontitis

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Randomized trial demonstrates 78c treatment reduces alveolar bone loss in mice with periodontitis, suggesting a new approach for therapy.

The study aims to evaluate whether the CD38 inhibitor 78c can enhance NAD+ levels and mitigate bone loss in periodontitis-affected mice.
Twenty young and twenty old male C57BL/6J mice with experimental periodontitis were treated with vehicle or 78c for 4 weeks.
Treatment involved intraperitoneal injections administered twice daily.
NAD+ levels were measured in the liver and spleen, while alveolar bone loss was assessed using micro-CT and histological staining.
78c treatment significantly increased NAD+ levels in the liver and spleen of both young and old mice.
In old mice, treatment with 78c also significantly raised NAD+ levels in the right maxilla.
Alveolar bone loss was alleviated in both young and old mice receiving 78c treatment.

Yarbrough et al. (2026) studied this question.

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View Full Paper

Ask AI

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Authors

Randomized trial demonstrates 78c treatment reduces alveolar bone loss in mice with periodontitis, suggesting a new approach for therapy.

The study aims to evaluate whether the CD38 inhibitor 78c can enhance NAD+ levels and mitigate bone loss in periodontitis-affected mice.
Twenty young and twenty old male C57BL/6J mice with experimental periodontitis were treated with vehicle or 78c for 4 weeks.
Treatment involved intraperitoneal injections administered twice daily.
NAD+ levels were measured in the liver and spleen, while alveolar bone loss was assessed using micro-CT and histological staining.
78c treatment significantly increased NAD+ levels in the liver and spleen of both young and old mice.
In old mice, treatment with 78c also significantly raised NAD+ levels in the right maxilla.
Alveolar bone loss was alleviated in both young and old mice receiving 78c treatment.

Yarbrough et al. (2026) studied this question.

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