Key result
Insulin infusion into hyperechogenic tissue is not associated with altered short-term glycemic outcomes.
Why the study?
Ultrasound frequently identifies hyperechogenic tissue at recent insulin infusion sites in youth using automated insulin delivery, but its short-term clinical significance remains unclear.
Does insulin infusion into ultrasound-detected hyperechogenic tissue alter short-term glycemic variation or insulin dose requirements compared to normoechogenic tissue in youth using automated insulin delivery?
Observational (n=17)
Does insulin infusion into ultrasound-detected hyperechogenic tissue alter short-term glycemic variation or insulin dose requirements compared to normoechogenic tissue in youth using automated insulin delivery?
Binary ultrasound classification of infusion sites as hyperechogenic or normoechogenic does not explain short-term glycemic variation in youth using automated insulin delivery.
No short-term glycemic impact from hyperechogenic sites in youth; leaves open prospective validation of infusion-set timing.
Background: Ultrasound frequently detects hyperechogenic tissue at recent insulin infusion sites in youth using automated insulin delivery, but its short-term clinical significance is unclear. Methods: In this post hoc paired analysis of a prior 4-week prospective study, participants were included if they had both hyperechogenic and normoechogenic findings at the most recently used infusion site across 3 visits. Insulin dose and continuous glucose monitoring metrics from days 1 to 2 after infusion-set placement were compared within participants. Results: Seventeen participants met the inclusion criteria. Insulin dose and continuous glucose monitoring–derived outcomes did not differ significantly between tissue categories. Time since infusion-set removal differed between categories (1.6 vs 2.1 days, P = .049). Conclusions: In this paired analysis, binary ultrasound classification alone did not explain short-term glycemic variation.
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Bjerrekær et al. (2026) conducted an observational in Youth using automated insulin delivery (n=17). Infusion into hyperechogenic tissue vs. Infusion into normoechogenic tissue was evaluated on Insulin dose and continuous glucose monitoring metrics. Infusion of insulin into hyperechogenic tissue did not significantly alter short-term glycemic outcomes, though time since infusion-set removal differed (1.6 vs 2.1 days, P=0.049).
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