Antimicrobial Resistance in Agroecosystems: One Health Strategies for Detection, Mitigation, and Sustainable Solutions

Antimicrobial resistance (AMR) in agroecosystems is a critical global health challenge driven by the overuse of antibiotics in agriculture, accelerating the spread of antibiotic-resistant bacteria (ARB) and genes (ARGs) across environments and food chains. To contain this threat, the One Health framework is essential, coordinating surveillance and intervention across human, animal, and environmental sectors. Recent technological advances, particularly biosensor-based monitoring, enhance this integrated approach by enabling the rapid, on-site detection of both antimicrobial residues in food and water and ARGs in the environment, providing crucial real-time data. When aligned with multi-omics integration, AI-driven surveillance, and sustainable remediation strategies like bioremediation and biochar amendments, these tools offer transformative pathways for effective AMR management, strengthening antimicrobial stewardship and safeguarding both food security and public health.