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This review aims to provide insights into the role of autologous transplantation for leukaemias, highlighting evolving strategies.

July 1, 2026Hematology ReportsOpen Access

Role of Autologous Haematopoietic Transplantation in Leukaemias: When to Consider It in 2026

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This review aims to provide insights into the role of autologous transplantation for leukaemias, highlighting evolving strategies.
Reviewed historical development and limitations of autologous transplantation in leukaemias.
Summarized recent strategies for stem cell purification and enhancing immune activity.
Discussed advancements in measurable residual disease assessment and molecular risk stratification.
Identified plasma cell leukaemia as a standard first-line approach for autologous transplantation.
Noted that selected AML subtypes and acute promyelocytic leukaemia can achieve outcomes comparable or superior to allogeneic transplantation.
Acknowledged limited utility in chronic lymphocytic leukaemia and chronic myeloid leukaemia, while promising strategies may expand applications.

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Review finds that autologous transplantation is vital for specific leukaemia types, suggesting personalized therapies could evolve.

Udvardy et al. (2026) studied this question.

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