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July 1, 2026mSphereOpen Access

Systems analysis reveals alternate metabolic states adopted by Mycobacterium tuberculosis across species

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Authors

JPJonathan Padilla‐GómezRMRachel A. McGinnVAVictoria Andrade

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Overview

Randomized trial shows metabolic differences in Mycobacterium tuberculosis infection in human and mouse macrophages, indicating host lipid pathways' influence on survival strategies.

Key Points

  • The study aims to understand how different host species influence the metabolic states of Mycobacterium tuberculosis during infection.
  • Cross-species transcriptomics compared metabolic programs in human and mouse macrophages.
  • Pharmacologic inhibition of diacylglycerol acyltransferase 1 was performed in human macrophages to assess effects on intracellular lipid inclusions.
  • Intracellular lipid inclusions formed in murine macrophages were analyzed versus human macrophages.
  • Mtb formed intracellular lipid inclusions (ILIs) in mouse macrophages but not in human macrophages, despite equal lipid availability.
  • Host triacylglycerol synthesis was inversely correlated with bacterial lipid storage.
  • Pharmacologic inhibition partially restored ILI formation in human macrophages, revealing a host lipid sequestration mechanism.

Cite This Study

Padilla‐Gómez et al. (2026) studied this question.

synapsesocial.com/papers/6a44ae605cd2549c8bc43a9bhttps://doi.org/10.1128/msphere.00141-26
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