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July 1, 2026Hemodialysis International

Nonlinear Association Between Serum Uric Acid Levels and Mortality in Maintenance Hemodialysis Patients: A Retrospective Study From the Beijing Hemodialysis Quality Control and Improvement Center

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Authors

HZHuixian ZhangZDZongli DiaoWGWang Guo

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Overview

Retrospective study investigates serum uric acid's impact on mortality in hemodialysis patients, highlighting a U-shaped relationship.

Key Points

  • To explore how serum uric acid levels correlate with all-cause and cardiovascular mortality in maintenance hemodialysis patients.
  • Included 2070 hemodialysis patients registered in 2014 from a quality control database.
  • Patients categorized into low, intermediate, and high serum uric acid groups.
  • Analyzed survival using Kaplan-Meier curves, log-rank test, and Cox proportional hazards models.
  • All-cause mortality rates were 42.3% (low), 17.7% (intermediate), and 30.4% (high) among grouped patients.
  • The intermediate group showed better survival than both low (HR 1.82, 95% CI 1.41-2.34, p<0.001) and high (HR 2.13, 95% CI 1.64-2.76, p<0.001) groups.
  • A U-shaped association was observed, indicating lowest risks at serum uric acid levels between 388-420 μmol/L.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a44ae8c5cd2549c8bc43b76https://doi.org/10.1111/hdi.70105
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