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July 1, 2026The Lancet Regional Health - AmericasOpen Access

Ultra-processed food intake and risk of renal cell carcinoma in the NIH-AARP Diet and health study: a prospective cohort analysis

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Authors

KBKaelyn F BurnsMPMark P. PurdueNKNeha Khandpur

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Overview

Prospective cohort analysis finds higher ultra-processed food intake raises renal cell carcinoma risk, suggesting a dietary link.

Key Points

  • To examine the association between ultra-processed food intake and the risk of renal cell carcinoma.
  • Participants without a cancer history at baseline were followed from 1995 to 2018.
  • Dietary intake was assessed using a food frequency questionnaire, categorizing items by Nova classifications.
  • Multivariable Cox proportional hazards models were used to estimate hazard ratios for RCC by UPF quartiles.
  • Higher UPF intake was linked to increased RCC risk [HR Q4 vs Q1 = 1.16 (1.05–1.29), p-trend = 0.0006].
  • Increased cc-RCC risk was noted with high UPF intake [HR = 1.38 (1.17–1.62), p-trend <0.0001].
  • Adjustments for BMI, diet quality, and hypertension weakened these associations.

Cite This Study

Burns et al. (2026) studied this question.

synapsesocial.com/papers/6a44aeba5cd2549c8bc43d0dhttps://doi.org/10.1016/j.lana.2026.101548
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