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July 1, 2026Çukurova medical journal (Online)/Çukurova medical journalOpen Access

Effects of urolithin A on adipogenesis, lipogenesis, and lipolysis in 3T3-L1 adipocytes: an experimental study

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MBMehmet BerközSYSerap Yalın

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Overview

Experimental study investigates urolithin A's impact on lipid metabolism in adipocytes, highlighting potential obesity prevention.

Key Points

  • The central aim was to examine the inhibitory effects of urolithin A on pre-adipocyte differentiation and related lipid metabolism pathways.
  • 3T3-L1 adipocytes were treated with urolithin A at concentrations ranging from 0 to 500 µM.
  • Measurements included GPDH activity, lipid accumulation, triglyceride levels, and gene expression.
  • Cytotoxic effects were assessed alongside changes in adipogenic and lipogenic gene activity.
  • Urolithin A decreased lipid content in adipocytes by 18.4–29.3% and increased free glycerol release by 11.23–39.56%.
  • No significant cytotoxicity was noted at 10–50 µM concentrations (1.8–8.2%).
  • The IC50 value for urolithin A was identified as 563.82 µM, with marked reductions in adipogenic and lipogenic gene expression.

Cite This Study

Berköz et al. (2026) studied this question.

synapsesocial.com/papers/6a44aeba5cd2549c8bc43e0ehttps://doi.org/10.17826/cumj.1891953
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