To Evaluate the Pharmacological Efficacy of Two Varieties of Kutaja (Holarrhena Antidysenterica. Wall. & Wrightia Tinctoria R. Br.) in Comparison With Standard Drug Madanaphala (Catunaregam Spinosa (Thunb.) in the Management of Psoriasis

This randomized controlled prospective single-blind clinical study evaluated the efficacy of Sadyo Vamana Karma using three Vamakadravyas - Wrightia tinctoria (Roxb.), Holarrhena antidysenterica (L.) Wall, and Catunaregam spinose (Thumb) - in treating Kitibha Kusṭa (Psoriasis). 45 patients were divided into three groups and treated with Sadyo Vamana Karma followed by Shamana Cikitsa for 30 days. Results showed that Catunaregam spinose (Thumb) induced Vamana faster (6.5 min) with better quality of first Vega (46.66% self-induced and projectile). Wrightia tinctoria (Roxb.) induced more Vega (5.4 avg.) with better Vaigiki Śuddhi. All three groups showed significant improvements in psoriasis symptoms, with Wrightia tinctoria (Roxb.) showing notable reductions in ŚyāvaVarṇa (P < 0.0001) and PASI Score (P < 0.0001). The study concludes that Catunaregam spinose (Thumb) and Wrightia tinctoria (Roxb.) are effective in inducing Vamana Karma, while Wrightia tinctoria (Roxb.) is more effective in treating psoriasis symptoms.