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This study aims to evaluate how amoxicillin and azithromycin affect the surface roughness of primary enamel and restorative materials.

July 1, 2026BMC Oral HealthOpen Access

Evaluation of pediatric drugs on the surface roughness of primary enamel and restorative materials: an in vitro study

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This study aims to evaluate how amoxicillin and azithromycin affect the surface roughness of primary enamel and restorative materials.
Included 90 specimens: 30 primary enamel, 30 Cention N, 30 RMGI, divided into subgroups (n=10) by immersion medium.
Measured surface roughness using a contact profilometer before and after three 7-day immersion cycles with 2-day intervals.
Statistical analysis involved Shapiro–Wilk test and ANOVA for comparing means with p ≤ 0.05 as significant.
Amoxicillin and azithromycin significantly increased surface roughness compared to artificial saliva (p < 0.001 for amoxicillin, p = 0.001 for azithromycin).
No significant difference in roughness increase between amoxicillin and azithromycin (p = 0.999).
Primary enamel showed a lower increase in roughness than Cention N and RMGI.

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In vitro study assessing drugs' effects on dental surfaces indicates notable roughening in materials tested.

Khalifa et al. (2026) studied this question.

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