Detecting Androgenetic Origin of the Genome via Single‐Nucleotide Polymorphism–Based Cell‐Free DNA Screening in Dichorionic Diamniotic Twin Pregnancies With Complete Hydatidiform Moles and a Coexisting Normal Fetus: A Three‐Case Report

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Key Points

The aim is to investigate androgenetic origins in pregnancies complicated by complete hydatidiform moles using SNP-based cell-free DNA methods.
Examined three cases of dichorionic diamniotic twin pregnancies.
Utilized single-nucleotide polymorphism (SNP) analysis on cell-free DNA samples.
Documented findings regarding the genetic origins of hydatidiform moles.
Successful identification of androgenetic origins in all three cases.
Distinct genetic profiles observed, differentiating normal and abnormal fetuses.
Findings support the utility of SNP-based screening for diagnosis in complex pregnancies.

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Case report reveals use of cell-free DNA screening to detect genomic origins in twin pregnancies, suggesting new diagnostic approaches.

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Yang et al. (2026) studied this question.

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