Noninvasive High-Voltage Microcurrent Therapy as an Adjunct to Standard Care in Early-Stage Diabetic Foot Ulcers: A Descriptive Case Series

Diabetic foot ulcers (DFUs) are a major cause of morbidity and non-traumatic lower-limb amputation, with delayed healing commonly associated with microcirculatory impairment, chronic inflammation, neuropathy, and lymphatic dysfunction. Electrical stimulation has been investigated as an adjunctive approach to support wound repair through modulation of bioelectric signaling. In this descriptive case series, five patients with early-stage DFUs received adjunct noninvasive high-voltage microcurrent therapy (HVMT) in addition to standard wound care. Serial wound assessments, including photographic documentation, demonstrated progressive wound contraction, formation of granulation tissue, and epithelialization during the treatment period. No device-related adverse events were observed. These preliminary findings suggest that adjunct HVMT is clinically feasible and well tolerated in patients with early-stage DFUs receiving standard care. However, due to the uncontrolled design and small sample size, these findings should be interpreted as descriptive, hypothesis-generating observations and not as evidence of therapeutic efficacy.