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Demonstrates efficacy of HDAC6 selective inhibitors in cancer treatment, suggesting potential as alternative therapies.
Synthesis and SAR of Isoform selective HDAC6 inhibitors of novel imidazoquinazolinones is shown. It demonstrates HDAC6 selective pharmacokinetic properties and has clean off-target profile. It shows efficacy comparable to approved HDAC inhibitors.
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Kulkarni et al. (2026) studied this question.
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