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This research aims to analyze the most cited studies on malaria drug repurposing to identify methodologies and successful candidates.

July 1, 2026Malaria JournalOpen Access

Mapping the intellectual landscape of malaria drug repurposing: a systematic analysis of the 51 most cited studies

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This research aims to analyze the most cited studies on malaria drug repurposing to identify methodologies and successful candidates.
Systematic analysis of 51 most cited articles in malaria drug repurposing from Scopus database.
Extraction and synthesis of data on methodologies, drug candidates, targets, and outcomes.
Utilization of computational approaches, including molecular docking and virtual screening.
Molecular docking was the most frequent strategy, used in 31.4% of studies, with in vivo evaluations yielding the highest validation scores.
Promising drug candidates included methotrexate, lopinavir, and everolimus, showing efficacy in vitro and in vivo.
Integrating advanced techniques like machine learning enhanced synergy prediction and discovery efforts.

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Systematic analysis identifies key drug candidates in malaria repurposing, suggesting new treatment pathways.

Tizhe et al. (2026) studied this question.

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