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July 1, 2026Applied Microbiology and BiotechnologyOpen Access

N-terminal lipidation enhances membrane interaction and antifungal activity of a Trematocine-derived decapeptide

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Authors

DSDamiano SquitieriFMFederica MassaroMMMelinda Mariotti

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Overview

Randomized trial explores N-terminal lipidation's impact on antifungal activity in yeast isolates, suggesting a novel treatment approach.

Key Points

  • This research aims to determine how N-terminal lipidation impacts the membrane interaction and antifungal activity of Trem-4 against resistant fungal strains.
  • Trem-4 was modified with caprylic and myristic fatty acids to create two lipopeptides: Cap-T4 and Myr-T4.
  • Biophysical assays, including fluorescence and circular dichroism, assessed membrane interactions.
  • Antifungal efficacy was evaluated against 60 yeast isolates in both planktonic and biofilm states.
  • Both lipopeptides exhibited broad-spectrum activity against Candida spp. and Cryptococcus neoformans.
  • Cap-T4 showed consistent antifungal action across species, while Myr-T4 was more potent against C. auris.
  • Both compounds retained effectiveness against mature biofilms with notable metabolic disruption and structural damage.

Cite This Study

Squitieri et al. (2026) studied this question.

synapsesocial.com/papers/6a44afb45cd2549c8bc4494chttps://doi.org/10.1007/s00253-026-13929-4
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Also Consider

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  1. 1Exploring the molecular structure of lipids in the design of artificial lipidated antifungal proteins2024
  2. 2Trematocine-derived antimicrobial peptides from the Antarctic fish Trematomus bernacchaii: potent antibacterial agents against ESKAPE pathogens2024 · 3 citations
  3. 3Liposome formulation of a myristoylated antimicrobial peptide derived from Chionodracine: preparation, physico-chemical characterization and biological activity2026
  4. 4Expansion of the antibacterial spectrum of symmetrical amino acid-paired antifungal peptides through structural optimization2025
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